Long Circulation
Optimized circulation time,
maximizing the performance of payloads
One Platform, Infinite Versatility, Invinity™
Invinity™ is a next-generation nanomedicine platform with finely tunable particle architecture and surface charge,
designed for stable, efficient payload delivery in biological environments.
Critical Challenges in Nanomedicine
Protein Corona & Immune Clearance
When nanoparticles enter the body, proteins rapidly coat their surface—forming what’s known as a protein corona.
Once coated, the immune system often recognizes these particles as foreign material and clears them.
As a result, most of injected nanoparticles are removed by the liver and spleen before they ever reach the target site.
Unless this barrier is overcome, both precision diagnostics and precision therapeutics remain fundamentally limited.
Invinity™ Solution
Invisible Shield for Stealth Delivery
Principle 1
A Chemically Crosslinked, Biocompatible Polysaccharide Core
Invinity™ is a next-generation nanomedicine platform designed to remain stable in vivo and reach target lesions efficiently. By chemically crosslinking a biocompatible polysaccharide and precisely tuning surface charge, Invinity™ controls biodistribution, biological interactions, and circulation time in vivo. This platform also fundamentally suppresses protein corona formation.
Principle 2
Zwitterion-based Surface Charge Control
Conventional nanoparticles can shift in overall charge depending on the payload’s electrostatic properties, changing how they behave in vivo. Invinity™ addresses this by precisely controlling the type and ratio of surface functional groups to create a balanced zwitterionic structure, where positive (+) and negative (–) charges are harmonized. As a result, Invinity™ maintains a stable, near-neutral surface charge—regardless of the payload.
Principle 3
Hydration-layer to Block Protein Binding
The surfaces of invinity™ can attract water molecules, forming a stable hydration layer around the particle. This hydration layer acts as a physical barrier, preventing proteins from directly binding to the particle surface. With protein corona formation suppressed, Invinity™ can better evade immune-cell uptake and reach target lesions more effectively.
Principle 1
A Chemically Crosslinked, Biocompatible Polysaccharide Core
Invinity™ is a next-generation nanomedicine platform designed to remain stable in vivo and reach target lesions efficiently. By chemically crosslinking a biocompatible polysaccharide and precisely tuning surface charge, Invinity™ controls biodistribution, biological interactions, and circulation time in vivo. This platform also fundamentally suppresses protein corona formation.
Principle 2
Zwitterion-based Surface Charge Control
Conventional nanoparticles can shift in overall charge depending on the payload’s electrostatic properties, changing how they behave in vivo. Invinity™ addresses this by precisely controlling the type and ratio of surface functional groups to create a balanced zwitterionic structure, where positive (+) and negative (–) charges are harmonized. As a result, Invinity™ maintains a stable, near-neutral surface charge—regardless of the payload.
Principle 3
Hydration-layer to Block Protein Binding
The surfaces of invinity™ can attract water molecules, forming a stable hydration layer around the particle. This hydration layer acts as a physical barrier, preventing proteins from directly binding to the particle surface. With protein corona formation suppressed, Invinity™ can better evade immune-cell uptake and reach target lesions more effectively.
From Circulation to Clearance
Designed for Performance at Every Stage
Invinity™ is designed for optimal pharmacokinetics—from circulation and target delivery to clearance—
enhancing performance across both diagnostics and therapeutics.
Target Specificity
Selective tissue targeting,
higher efficacy, lower off-target exposure
Thorough Excretion
Minimal organ retention
and safe excretion
From Circulation to Clearance
Designed for Performance at Every Stage
Invinity™ is designed for optimal pharmacokinetics—from circulation and target delivery to clearance— enhancing performance across both diagnostics and therapeutics.
Long Circulation
Optimized circulation time, maximizing the performance of payloads
Target Specificity
Selective tissue targeting, higher efficacy, lower off-target exposure
Thorough Excretion
Minimal organ retention and safe excretion
From Circulation to Clearance
Designed for Performance at Every Stage
Invinity™ is designed for optimal pharmacokinetics—from circulation and target delivery to clearance—enhancing performance across both diagnostics and therapeutics.
Long Circulation
Optimized circulation time, maximizing the performance of payloads
Target Specificity
Selective tissue targeting, higher efficacy, lower off-target exposure
Thorough Excretion
Minimal organ retention and safe excretion
Payload Modularity
Versatility Across Diagnosis and TreatmentVersatility Across
Diagnosis and Treatment
The true value of Invinity™ lies in its versatility.
Invinity™ can accommodate
a wide range of payloads,
enabling applications from
diagnostic to therapeutic nanomedicines.
Powered by Invinity™, Inventera is advancing
nano-MRI contrast agents toward commercialization
and expanding into
next-generation therapeutics.
Payload Modularity
Versatility Across Diagnosis and TreatmentVersatility Across
Diagnosis and Treatment
The true value of Invinity™ lies in its versatility.
Invinity™ can accommodate
a wide range of payloads,
enabling applications from
diagnostic to therapeutic nanomedicines.
Powered by Invinity™, Inventera is advancing
nano-MRI contrast agents toward commercialization
and expanding into
next-generation therapeutics.
Nanomedicines Powered by Invinity™
Nano-MRI Contrast Agent
Invinity™ + MRI contrast material (iron oxide)
Disease-specific nano-MRI contrast agents for precise diagnosis
#INV-002#INV-001#INV-003#INV-00X
Invinity™-Drug Conjugates
Invinity™ + small molecule drugs or peptides
Nanoformulation for improved solubility and delivery
#PoC Stage
Invinity™-ADC
Invinity™ + small molecule drugs + antibody
Next-generation ADC for multi-payload designs, higher DAR, and greater stability
#PoC Stage
FAQ
A protein corona is a layer of proteins that adsorbs onto the surface of nanoparticles when they are exposed to biological fluids. This layer can change a nanoparticle’s biological identity and influence its biodistribution and immune response.
